【学术报告】Oligonucleotide conjugates: From carrier-free intracellular delivery to extension of blood circulation
日期：2024-05-02
阅读：759
主题：Oligonucleotide conjugates: From carrier-free intracellular delivery to extension of blood circulation
报告人：谈栩宇 博士
时间：2024年5月2日（周四）14:00-17:00
地点：霞光楼220会议室
邀请人：王大力 副教授
个人简介
Dr. Xuyu Tan obtained his BS degree in 2013 in Chemistry from Hong Kong Polytechnic University. He then studied polymer chemistry with Prof. Ke Zhang at Northeastern University in Boston, focusing on carrier-free intracellular delivery of oligonucleotide conjugates. After graduation in 2018, Dr. Tan was a postdoctoral fellow in the laboratory of Prof. Bradley Pentelute at Massachusetts Institute of Technology, focusing on de novo peptide synthesis and library screening. Dr. Tan worked as a research scientist at Johnson & Johnson from 2021 to 2022, focusing on high-throughput synthesis of lipid-siRNAs and their extrahepatic delivery. He is now a research scientist II at Sarepta Therapeutics, dealing with discovery of novo cell-penetrating peptides for PMO oligonucleotide delivery. His current research interests include oligonucleotide and/or peptide synthesis/delivery and bioconjugation.
报告摘要
Oligonucleotides are informational drugs that have great potential to treat rare diseases. Only a handful of oligonucleotide drugs, however, have been approved by FDA, despite their well-known mechanisms and over 40 years of development. Delivery of unmodified oligonucleotides remains challenging due to their low cell uptake and degradable backbone. This presentation focuses on oligonucleotide conjugates that can profoundly change the PK/PD profile of oligonucleotides. Synthesis of oligonucleotide-drug conjugates will be covered to achieve carrier-free intracellular delivery, and ligands such as cell-penetrating peptides (CPPs) and lipids will be discussed to tune diverse tissue distribution and efficacy of these conjugates.
