购彩中心

题目： Aggregation-Induced Emission: Materials and Biomedical Applications
演讲人：Professor Bin Liu, National University of Singapore 
时间：5月24日（星期五），下午13:30
地点：化学楼A-528会议室
邀请人：樊春海 教授




报告人简介：
 


Bin Liu received BS degree from Nanjing University and Ph.D. degree from the National University of Singapore (NUS) before her postdoctoral training at the University of California, Santa Barbara. She joined the Chemical and Biomolecular Engineering Department of NUS in late 2005. She was promoted to Associate Professor in 2010 and was named as Chair Professor in 2014. Her current research focuses on organic nanomaterials for biomedical and energy applications. Dr. Liu has received many highly prestigious awards, including Singapore President’s Young Scientist Award 2008, L’Oréal Women in Science National Fellowship 2011, Asia Rising Star 2013, BASF Materials Award 2014, Materials in Society Lectureship 2015, Singapore President’s Technology Award 2016, and Asian Scientist Top 100 List in 2017. Dr. Liu was named as The World’s Most Influential Minds and the Top 1% Highly Cited Researchers in Materials Science by Thomson Reuters during 2014-2017. Dr. Liu is the Fellow of Singapore Academy of Engineering, Asia-Pacific Academy of Materials, the Royal Society of Chemistry and serves as the Deputy Editor for ACS Materials Letters.

Keywords: Aggregation-induced emission; AIE light-up probes; AIE dots; Image-guided therapy; Image-guided surgery


Abstract: The recent years have witnessed the fast grow of fluorogens with aggregation-induced emission characteristics (AIEgens) in biomedical research. The weak emission of AIEgens as molecular species and their bright luminescence as nanoscopic aggregates distinguish them from conventional organic luminophores and inorganic nanoparticles, making them wonderful candidates for many high-tech applications. In this talk, we summarize our recent AIE work in the development of new fluorescent bioprobes for biosensing and imaging.[1,2] The simple design and fluorescence turn-on feature of the molecular AIE bioprobes offer direct visualization of specific analytes and biological processes in aqueous media with higher sensitivity and better accuracy than traditional fluorescence turn-off probes. The AIE dot probes with different formulations and surface functionalities show advanced features over quantum dots and small molecule dyes in noninvasive cancer cell detection, long term cell tracing, and vascular imaging.[3] In addition, our recent discovery that AIEgens with high brightness and efficient reactive oxygen species generation in aggregate state further expanded their applications to image-guided cancer surgery and therapy. 


References: 
1. D. Ding, K. Li, B. Liu, and B. Z. Tang, Acc. Chem. Res. 2013, 46, 2441–2453.
2. J. Liang, B. Z. Tang, and B. Liu, Chem. Soc. Rev. 2015, 44, 2798–2811.
3. K. Li and B. Liu, Chem. Soc. Rev. 2014, 43, 6570–6597.