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题目：Synthetic Nanovaccine For Cancer Immunotherapy
演讲人：罗敏，复旦大学生物医学研究院研究员，青年千人
时间：2018年5月16日（周三）14：00-
地点：系统生物医学研究院D405会议室
邀请人：张川特别研究员，朱新远教授

Abstract：
Although vaccination is historically one of the most successful strategies for the prevention of infectious diseases, development of vaccines for cancer and many chronic infections, such as HIV, malaria, and tuberculosis, has remained a challenge. Strong and long-lasting antigen-specific T cell responses are critical for therapy of these diseases. 

A major challenge in achieving a robust CD8+ T cell response is the requirement of spatio-temporal orchestration of antigen cross-presentation in antigen-presenting cells with innate stimulation. 

I would discuss the development of nanoparticle vaccine (nanovaccine) that modulates the innate immune system and enhances adaptive immunity with reduced toxicity. We address how nanovaccines can integrate multiple functions, such as lymph node targeting, antigen presentation, and stimulation of innate immunity, to achieve a robust T cell response for immunotherapy. 
 
Short BIOGRAPHY
罗敏，博士现为复旦大学生物医学研究院研究员及博士生导师，2018年入选中组部青年千人计划。先后在北京大学获得学士与博士学位，并在美国西南医学研究中心西蒙斯癌症中心工作多年。致力于肿瘤与慢性传染性疾病的分子机制研究及药物、疫苗的开发，迄今已有22篇论文发表在国际刊物。近期的研究成果以第一作者在Nature Nanotechnology，Angew. Chem., Journal of Controlled Release, Cell Research等学术期刊发表。